Showing posts with label cyclic adenosine monophosphate signaling system. Show all posts
Showing posts with label cyclic adenosine monophosphate signaling system. Show all posts

Tuesday, November 13, 2012

Moody or Bipolar?


“You’re so bipolar!” My siblings would throw around that phrase when we had unexplainable mood swings. Never did we give a thought of what it really meant or that one of us would someday be diagnosed with it.  I always knew my brother was a little “crazy”.  He would get so hyper and run around sometimes and then be blissful and then just angry and antisocial.  Bipolar has three main subcategories: type I, type II, & cyclothymia.  Type I, previously known as manic depression, is basically one manic episiode (at least) and periods of major depression.  Type II is hypomania (not full mania but bursts of energy and impulsiveness) and episodes of depression.  Cyclothymia is less mood swings, but is similar to type II.  There are several symptoms like being easily distracted or poor judgment.  Each person varies with their symptoms and sometimes can even be diagnosed as depressed instead of bipolar.  The hyperlink above on bipolar gives detailed symptoms as well as treatment and mood stabilizers that are usually used.  Bipolar is an actual disorder and not something that should be taken lightly.

I’ve always wondered what causes it, how can a doctor be sure that someone really has a bipolar disorder and what part does genetics play? (Click genetics to access the article)  The Scripps Research Institute has found variations in genes that increase the risks of bipolar disorder.  Those genes appear to be associated with a biochemical pathway know as cyclic adenosine monophosphate (cAMP) signaling system.  About 29 genes determine if someone’s risk is higher than another persons. 
This disorder is 5 to 6 more likely to happen in someone that has a sibling or family member with bipolar so I find it interesting that testing one’s genes can tell a person’s possible story before they even live it (so to speak just because someone has a higher risk doesn’t necessarily mean they’ll get it).  The video below is of girl explaining what it’s like to live with the disorder.  She goes into what it is, how it feels, and types of treatment she’s tried.  Hearing her personal struggle and how treatments are different in everyone makes it feel more real and easy to relate to.  Finding the right “concoction” is important and does make a difference on how a person reacts from day to day.  I also found it really cool that psych central has a screening quiz so the link on the bottom of the video.